May 28, 2016
Highlights at the 2016 AUA Annual Meeting in San Diego, Ca
The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators - presented 13 abstracts in moderated poster or podium presentations at the American Urological Association (AUA) Annual Meeting, May 6-10, 2016, San Diego, CA. The team was co-led by COL David McLeod, (Ret), MD, CPDR Director and Professor of the Department of Surgery, Uniformed Services University of the Health Sciences (USU) and the Walter Reed National Military Medical Center (WRNMMC); Dr. Shiv Srivastava, CPDR Co-Director and Professor in the Department of Surgery at USU and WRNMMC; COL Inger Rosner, MD, Associate Director, CPDR and Associate Professor, Department of Surgery, USU and the WRNNMC; Dr. Jennifer Cullen, Director of Epidemiology Research Program, CPDR and Research Assistant Professor, Department of Surgery, USU and WRNMMC and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, Department of Surgery , USU and WRNMMC.
2016 Best of Posters Award
The abstract titled "ERG Induces Endoplasmic Reticulum Stress and Unfolded Protein Response to Initiate Prostate Cancer Carcinogenesis” presented by Dr. Taduru Sreenath, Assistant Director, CPDR and Research Associate Professor, Department of Surgery, USU and the WRNMMC, has won the “2016 Best of Posters Award ” in the Moderated Poster Session number MP84-10. The importance of this study was the first demonstration of ERG’s role as a crucial mediator of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) leading to cell survival through clonal selection. These observations also define potential new therapeutic targets in CaP-ERG network.
Pictured left - Amina Ali, Dr. Jennifer Cullen, Dr. Taduru Sreenath, and Dr. Shiv Srivastava
2016 AUA Press Program
The abstract titled “Higher Frequency of Germline BRCA1 and BRCA2 Mutations in African American Prostate Cancer” presented by Dr. Gyorgy Petrovics , Associate Director, CPDR and Research Associate Professor, Department of Surgery, USU, was chosen for inclusion in the 2016 AUA Press Program. This work was a collaborative effort co-led by Dr. Michael Dean, with the National Cancer Institute at NIH and Dr. Shiv Srivastava, CPDR Co-Director. Fewer than 30 out of 2700 abstracts were selected for this Press Program. The crucial finding of this study was that inherited mutations in BRCA genes are significantly more frequent in African American prostate cancer patients compared to Caucasian Americans.
Pictured left - Dr. Gyorgy Petrovics, Amina Ali, and Dr. Judd Moul
Since 1993, CPDR, the Department of Surgery at USUHS, and the Urology Service at WRNMMC have been training the medical and Urology residents. Dr. Daniel Kim, a fifth year medical resident at the Walter Reed National Military Medical Center (WRNMMC), presented novel work in a Podium Presentation Session. Dr. Kim's presentation, entitled "Nuclear Grade Predicts Prostate Cancer (Cap) Outcomes Among Radical Prostatectomy Patients", under the guidance of Dr. Isabell Sesterhenn, Chief of Genitourinary (GU) Pathology, Joint Pathology Center and Director of GU Pathology Research, CPDR and Dr. Jennifer Cullen, Director of CPDR Epidemiology Research highlighted the importance of the nuclear grade in predicting CaP progression, using whole mount prostatectomy specimens from patients undergoing surgery at WRNMMC who enrolled in the CPDR linked clinical and biospecimen data repositories. This patient cohort is unique in its over-representation of African American patients, as well as its equal access health care setting. Nuclear grade will continue to be an active area of interest to the CPDR translational research team.