CPDR Integrated Biomedical Informatics Platform
Developing Effective Prevention, Diagnostic and Treatment Strategies
The infrastructure of Integrated Biomedical Informatics Platform (IBIP) has been established with business requirement analysis, platform blueprint, implementation strategies, and organization-wide policies, standards on information management and information system development. Program-specific resource informatics systems are also constructed via setting up sophisticated and robust information systems and tools in each research program to streamline the in-house information management by its own requirements. The construction of those systems follows policies, standards and SOPs regulated by the platform. They can be deployed onto IBIP, which:
- Enable the programmable connection between resource informatics systems and the platform as a network to facilitate data communication, and to implement interoperability
- Facilitate dynamic and seamless interdisciplinary data integration and annotation via dynamic data binding
- Provide systematic solution to data quality monitoring and control, data query, data sharing, distribution and version control.
- Provide comprehensive strategies and solution to information security, human privacy protection and regulatory compliance on data collection, integration, analysis and management
- Establish policies, standards, and SOPs on organization level and research program level for operation within information system, data management, and information sharing in collaboration
- Provide professional administration on information system and databases
Patient's privacy protection and data security are two most critical and most challenging factors regarding the research data management. Within IBIP, multiple strategies are applied to ensure the privacy protection and data security.
Privacy protection is ensured by processes of automated data de-identification and centralized patient identification. De-identification enforces the filtering and localized storage of demographic information collected by data management systems. Centralized patient identification will make sure patients consenting to the program are uniquely assigned a random selected identification number, which will serve as the primary patient identification in centralized, de-identified research data pool, and the only linkage between local demographic databases and central research databases.
2018 AACR Annual Meeting
Chicago, Illinois April 14-18, 2018
The 2018 AACR Annual Meeting gathered this year at McCormick Place, Chicago, Illinois from April 14 to 18 under the theme of Driving Innovative Cancer Science to Patient Care. The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators – delivered one podium presentation and 12 poster presentations. The team was co-led by Dr. Shiv Srivastava, CPDR Co-Director and Professor, and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, of the Department of Surgery, USU and WRNMMC.
Read the March 2019 CPDR E-Newsletter
ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development
Scientific Reports | 7: 1109 | DOI:10.1038/s41598-017-01187-4
Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Mol Cancer Res. 2017 Oct;15(10):1308-1317. doi: 10.1158/1541-7786.MCR-17-0058. Epub 2017 Jun 12.
Ethnicity and ERG Frequency in Prostate Cancer
Nat Rev Urol. 2017 Sep 5. doi: 10.1038/nrurol.2017.140. [Epub ahead of print]