CPDR Biospecimen Banks
New Challenges in Predicting the Clinical Course for CaP Patients
It is worth noting that well-characterized biospecimens from our group and others have already contributed immensely to the novel molecular discoveries made in the field of CaP research. Therefore, with a proven track record, the continued development and enhancement of the CPDR Biospecimen Bank holds great promise for much needed translational research at CPDR and at other institutions through collaborative research agreements.
The biospecimen storage and processing facilities that comprise the CPDR Biospecimen Bank are housed in four locations: the Walter Reed National Military Medical Center (WRNNMC) in Bethesda, MD; the headquarters of the Center for Prostate Disease Research (CPDR) in Rockville, MD; the Joint Pathology Center (JPC) in Washington, DC, and the Prostate Cell Center at the Department of Surgery of the Uniformed Services University (USU) in Bethesda, MD. These facilities have been processing biospecimens since 1993 and have a significant endowment of biospecimen resources. The biospecimen resources and analytical and processing services provided by these facilities have supported numerous studies conducted at the CPDR. These studies have resulted in over 60 peer-reviewed publications, 10 grants or CRADA, and five patents to date.
- Radical Prostatectomy Specimen Processing for Frozen Tissue Bank Generation
- Histological Characterization
- Radical Prostatectomy Specimen Processing for Fixed, Paraffin-embedded Tissue Bank Generation
- Laser Capture Microdissection (LCM) of Prostate Tissues and Generation of
LCM/RNA and Genomic DNA Bank
- Development of Tissue Microarrays (TMA)
- Peripheral Blood Collection and Processing to Generate Serum and genomic DNA Banks
- Serum Preparation
- Peripheral Blood DNA Bank
More recently, active collaborations have been sought by corporate partners and academic leaders to use CPDR Bio-specimens bank. A Biospecimen Oversight Committee and Research Opportunity Evaluation Committee have been instituted recently to monitor the prioritization of bio-specimens for in-house use and collaborations.
2018 AACR Annual Meeting
Chicago, Illinois April 14-18, 2018
The 2018 AACR Annual Meeting gathered this year at McCormick Place, Chicago, Illinois from April 14 to 18 under the theme of Driving Innovative Cancer Science to Patient Care. The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators – delivered one podium presentation and 12 poster presentations. The team was co-led by Dr. Shiv Srivastava, CPDR Co-Director and Professor, and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, of the Department of Surgery, USU and WRNMMC.
Read the March 2019 CPDR E-Newsletter
ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development
Scientific Reports | 7: 1109 | DOI:10.1038/s41598-017-01187-4
Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Mol Cancer Res. 2017 Oct;15(10):1308-1317. doi: 10.1158/1541-7786.MCR-17-0058. Epub 2017 Jun 12.
Ethnicity and ERG Frequency in Prostate Cancer
Nat Rev Urol. 2017 Sep 5. doi: 10.1038/nrurol.2017.140. [Epub ahead of print]