BASIC SCIENCE RESEARCH PROGRAM
Innovative Techniques Through Basic Science Research
The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.
The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.
- Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
- Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
- Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
- Delineation of hormonal mechanisms involved in prostate cancer onset or progression
- Development and evaluation of novel molecular therapeutic agents for prostate cancer
- Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
- Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
- Education and training of next generation of basic science and translational researchers in prostate cancer
Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.
2018 AACR Annual Meeting
Chicago, Illinois April 14-18, 2018
The 2018 AACR Annual Meeting gathered this year at McCormick Place, Chicago, Illinois from April 14 to 18 under the theme of Driving Innovative Cancer Science to Patient Care. The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators – delivered one podium presentation and 12 poster presentations. The team was co-led by Dr. Shiv Srivastava, CPDR Co-Director and Professor, and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, of the Department of Surgery, USU and WRNMMC.
Read the March 2019 CPDR E-Newsletter
ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development
Scientific Reports | 7: 1109 | DOI:10.1038/s41598-017-01187-4
Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Mol Cancer Res. 2017 Oct;15(10):1308-1317. doi: 10.1158/1541-7786.MCR-17-0058. Epub 2017 Jun 12.
Ethnicity and ERG Frequency in Prostate Cancer
Nat Rev Urol. 2017 Sep 5. doi: 10.1038/nrurol.2017.140. [Epub ahead of print]