Dr. Shyh-Han Tan, Ph.D..

Staff Scientist

Dr. Tan, joined the Center for Prostate Disease Research (CPDR) Basic Science Research Program as a Staff Scientist in November 2007. Dr. Tan's focus is characterizing the mechanisms of how ERG oncogene expression changes the biology of prostate cell differentiation and stimulates prostate cancer progression. He also contributes to the effort on translational research through his work to enhance the bio-specimen banking operations and in the development of methods for detection of circulating prostate cancer cells.

Dr. Tan obtained his B.Sc (Honors) in Microbiology from the National University of Singapore. For his Ph.D. thesis, Dr. Tan researched the transcription regulation of the Human Papillomavirus type-16 (HPV-16) under the mentorship of Dr. Hans-Ulrich Bernard at the Institute of Molecular and Cell Biology, National University of Singapore. After earning his Ph.D. in 1996, Dr. Tan continued to work with Dr. Bernard as a postdoctoral research fellow, where he mapped and analyzed the matrix attachment regions (MARs) in the genome HPV-16, and its effect on HPV transcription. He received the NIH Intramural Research Training Award to continue his postdoctoral training with Dr. Mary Dasso, at the National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health from 1999 to 2004. He studied the SUMO-modification pathway and characterized the SUMO isopeptidase, SUSP1, and its function in the formation of nuclear bodies.

Dr. Tan began his research in prostate cancer with Dr. Marja Nevalainen at the Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C.in 2005. He studied the function of the transcription factor signal transducer and activator of transcription 5 (STAT5) in androgen independent prostate cancer. He continued his research at the Kimmel Cancer Center at the Thomas Jefferson University, Philadelphia, where he contributed to the finding that STAT5 interacts synergistically with androgen receptor and may regulate androgen independent prostate cancer.

Dr. Tan has published his findings in peer-reviewed journals such as Journal of Virology, Journal of Cell Biology and Cancer Research. He also serves as supervisor to CPDR postdoctoral fellows and students.