basic sceince research

BASIC SCIENCE RESEARCH PROGRAM

Research Accomplishments

Research projects are integrated under the following themes which are highly interactive and are beyond the conventional boundaries of a given expertise area and truly represent the CPDR paradigm:

  • Translational CaP Genomics and Proteomics
  • Novel CaP Cell Culture Models
  • CaP Molecular Genetics
  • Hormonal Mechanisms of CaP


Translational CaP Genomics and Proteomics

Translational research of cancer cell and molecular biology-derived discoveries in the pre-clinical or clinical research setting has been the priority of CPDR since its inception. A highly multi-disciplinary research environment of urologists, cancer cell and molecular biologists, genitourinary pathologists, bioinformatics and medical informatics experts, bio-statisticians, medical technologists and regulatory affairs experts supports the CPDR enterprise. Well-characterized CPDR biospecimens banks, recent discoveries showing consistent gene expression alterations in CaP and development of promising new molecular diagnostic technologies, have provided an optimal setting for CPDR to focus in the translational research areas, where we already have developed expertise or in the areas where new initiatives are needed.

Novel Cell Culture Models of CaP

The Prostate Cell Center was established in the newly-renovated CPDR laboratory at the Department of Surgery, USUHS, in January 2000 and has been very active over the years. The Prostate Cell Center has made major advances in the generation of short-term cultures from primary tumors of prostate cancer patients. (1) Total cell strains generated from primary tumors are 134, (2) the number of cell strains generated from normal tissue from the same patient are 72, (3) five well-characterized telomerase-immortalized human CaP cell lines from the tumor of African American and caucasian CaP patients. These cells are critical to the development and use of in vitro models and for the identification of novel therapeutic targets of prostate cancer.

CaP Molecular Genetics

Since its inception, CPDR-BRP has embraced the goal of defining CaP-specific genetic alterations that characterize the disease onset and/or progression. Genetic alterations that are "critical" in the genesis of CaP or molecular alterations that "consistently associate" with CaP will provide definitive molecular targets for the development of bio-markers and new therapeutic targets. This goal has become increasingly more apparent as most of the frequent gene alterations associated with other common human cancers such as breast cancer, colon cancer or lung cancer, do not seem to play a significant role in CaP.

Defining Androgen Signaling in CaP Onset and Progression

Androgen signaling is extremely important in the life and death of the prostate gland and is believed to play an important role in prostate cancer. Hormonal therapy, the most common treatment strategy for the treatment of metastatic prostate cancer works by inhibiting androgen signaling. Accumulating evidence suggests that alterations of androgen signaling in prostate cancer may involve structural or functional alterations of the critical genes at numerous points in the pathway.

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CPDR September 2015
Distinguished Visiting Professor


Stefan Ambs, Ph.D., M.P.H.

Dr. AmbsSenior Investigator, Laboratory of Human Carcinogenesis, Head, Molecular Epidemiology Section, Center for Cancer Research, NCI, NIH

Presentation: "Environmental And Race/Ethnicity-Associated Signatures In Prostate Cancer"

Date: September 3, 2015
Time: 1100 - 1200
Location: CPDR, Rockville, MD
2nd floor conference room

For More Info Click Here

 

CURRENT EVENTS

WRNMMC UsToo!

Read the August 2015 WRNMMC UsToo! Newsletter

Go to WRNMMC UsToo! Newsletter Archive

 

July 20, 2015

CPDR's GHI publication is featured in the latest MDLinx "Best of Oncology"

 

April 21, 2014

Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans

 

March 30, 2014

CytoTest and Uniformed Services University’s Center for Prostate Disease Research enter into CRADA to advance cancer diagnosis and prognosis