BASIC SCIENCE RESEARCH PROGRAM
Innovative Techniques Through Basic Science Research
The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.
The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.
- Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
- Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
- Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
- Delineation of hormonal mechanisms involved in prostate cancer onset or progression
- Development and evaluation of novel molecular therapeutic agents for prostate cancer
- Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
- Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
- Education and training of next generation of basic science and translational researchers in prostate cancer
Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.
CPDR October 2014
Distinguished Visiting Professor
Peter L. Choyke, M.D., FACR
Molecular Imaging Program
Center for Cancer Research
National Cancer Institute, Bethesda, MD
Presentation: "The Future of Prostate Cancer
Imaging With MRI"
Date: OCTOBER 2, 2014
Time: 1100 - 1200
Location: CPDR, Rockville, MD
2nd floor conference room
Quarterly Guest Speakers
Dr. Valencia Clay
Palliative Care Physician, WRNMMC
Dr. Jerry Waddell
Psychologist and Program Director of the Palliative Care Service, WRNMMC
Presentation: "Quality of Life in Disease Progression"
Free and no registration required.
Date: Thursday, 6 November 2014
Time: 7-8:30 PM
Location: America Building, 2nd floor, Room 2525
(above the lab/pharmacy) and Fort Belvoir Community Hospital
(Oaks Pavilion, 1st floor, Room 332)
Contact: COL (ret) Jane Hudak for more information at 301-319-2918 or
Read the AUGUST 2014 Newsletter