basic sceince research


Innovative Techniques Through Basic Science Research

The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.

The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.



  • Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
  • Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
  • Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
  • Delineation of hormonal mechanisms involved in prostate cancer onset or progression
  • Development and evaluation of novel molecular therapeutic agents for prostate cancer
  • Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
  • Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
  • Education and training of next generation of basic science and translational researchers in prostate cancer


Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.

BSRP Leadership | Gene Expression Data | Research Achievements | BSRP Staff


CPDR Distinguished Guest Speaker

Dr. Annette Fenner

Chief Editor
Nature Reviews Urology

Presentation: "Editor’s Insights – the Nature of Urology"

Annette Fenner studied at Imperial College London, where she completed her medical degree and intercalated a BSc in Endocrinology and PhD in Reproductive Biology. During her PhD, she worked on hypothalamic peptides in the control of reproduction, with a particular focus on the role of kisspeptins. Bringing with her an interest in the field of sexual medicine, she joined the Nature Reviews Urology team as an Associate Editor in 2010, and was promoted to Chief Editor in 2011.

Date: 30 November 2015
Time: 11:00 AM - 12:00 PM
Location: CPDR Rockville, MD


WRNMMC UsToo! Newsletter

Read the November 2015 WRNMMC UsToo! Newsletter

Go to WRNMMC UsToo! Newsletter Archive


July 20, 2015

CPDR's GHI publication is featured in the latest MDLinx "Best of Oncology"


April 21, 2014

Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans