BASIC SCIENCE RESEARCH PROGRAM
Innovative Techniques Through Basic Science Research
The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.
The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.
- Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
- Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
- Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
- Delineation of hormonal mechanisms involved in prostate cancer onset or progression
- Development and evaluation of novel molecular therapeutic agents for prostate cancer
- Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
- Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
- Education and training of next generation of basic science and translational researchers in prostate cancer
Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.
Quarterly Guest Speakers
Associate Director, CPDR Basic Science Research Program
Research Assistant Professor of Surgery, USUHS
Presentation: "Recent Advancements in Prostate Cancer Detection, Prognosis, and
Date: 7 Aug 2014
Time: 7-8:30 PM
Location: WRNMMC, America Building, 2nd floor, Room 2525
Contact: COL (ret) Jane Hudak for more information
at 301-319-2918 or firstname.lastname@example.org
Read the AUGUST 2014 Newsletter
Expression of ERG Oncoprotein in Higher Grade Prostate Cancer in Caucasian American and African American Men
Farrell J, Young D, Chen Y, Degon M, Cullen J, Petrovics G, Rosner I, Kagan J, Srivastava S, McLeod DG, Sesterhenn IA and Srivastava S.
Molecular and Clinical Oncology 2014 (in press).
ERG Oncoprotein Expression Status In A Multi-Ethnic Cohort Of Cap Patients From Malaysia
Kelly GM, Kong YH, Tan S-H, Dobi A, Sesterhenn IA, Srivastava S, Pathmanathan R, Tan HM, Cheong SC.
Molecular and Clinical Oncology, 2014 (in press).
Legends in Urology: Fathollah Keshvar "Kash" Mostofi, MD. An Interview with Isabell Sesterhenn, MD
Canadian Journal of Urology (21) 3 Jun 2014.