BASIC SCIENCE RESEARCH PROGRAM
Innovative Techniques Through Basic Science Research
The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.
The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.
- Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
- Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
- Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
- Delineation of hormonal mechanisms involved in prostate cancer onset or progression
- Development and evaluation of novel molecular therapeutic agents for prostate cancer
- Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
- Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
- Education and training of next generation of basic science and translational researchers in prostate cancer
Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.
Quarterly Guest Speakers
Dr. Lloyd Glover
Presentation: "A Urologist is Diagnosed with Prostate
Cancer -- Now What?"
Date: August 4, 2014
Time: 7-8:30 PM
Location: WRNMMC, America Building, 2nd floor, Room 2525
Contact: COL (ret) Jane Hudak for more information at 301-319-2918 or
or go to theWRNMMC UsToo! Newsletter Archive
Read the JULY 2016 CPDR E-Newsletter
May 28, 2016
Highlights at the 2016 AUA Annual Meeting in San Diego, Ca
The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators - presented 13 abstracts in moderated poster or podium presentations at the American Urological Association (AUA) Annual Meeting, May 6-10, 2016, San Diego, CA. The team was co-led by COL David McLeod, (Ret), MD, CPDR Director and Professor of the Department of Surgery, Uniformed Services University of the Health Sciences (USU) and the Walter Reed National Military Medical Center (WRNMMC); Dr. Shiv Srivastava, CPDR Co-Director and Professor in the Department of Surgery at USU and WRNMMC; COL Inger Rosner, MD, Associate Director, CPDR and Associate Professor, Department of Surgery, USU and the WRNNMC; Dr. Jennifer Cullen, Director of Epidemiology Research Program, CPDR and Research Assistant Professor, Department of Surgery, USU and WRNMMC and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, Department of Surgery , USU and WRNMMC.
May 13, 2016
CPDR Student Participant Wins The AACR Gary J. Miller Undergraduate Prize for Cancer and Cancer Related Biomedical Research
A third place prize in the AACR Undergraduate Student Caucus and Poster Competition was awarded to Ms. Shahnoza Dusmatova, a CPDR participant in the DoD "Research and Education Program for Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI)".
May 2, 2016
CPDR Presentations and Highlights at the 2016 AACR Annual Meeting in New Orleans, La.
The Center for Prostate Disease Team has presented their new findings in prostate cancer research at the American Association for Cancer Research Annual Meeting 2016 in New Orleans, Louisiana, USA.
The Team led by Dr. David G. McLeod, Director and Dr. Shiv Srivastava, Co-Director presented the ground breaking discovery of the first recurrent cancer genomic defect of prostate cancers of African American men revealed by whole genome sequencing. The title of the poster presentation was “LSAMP gene deletion is associated with rapid disease progression in prostate cancer of African American men”.